Fig. 4

HSF1 inhibition reduces iNOS expression in brains from endotoxemic mice. Mice were divided into sham (saline + DMSO), endotoxemia (LPS 25 mg/kg + DMSO), KRIBB11 alone treatment (5 mg/kg), and LPS + KRIBB11 groups. Mice were sacrificed 20 h after injections and iNOS protein and mRNA levels were measured in brain tissues (a–c). As shown, KRIBB11 treatment significantly suppressed both iNOS protein (n = 3, *P < 0.05 vs. LPS alone-treated group; **P < 0.01 vs. control or KRIBB11 alone-treated group) and mRNA (n = 3, *P < 0.05 vs. control or LPS alone-treated group) expressions in brain tissues from endotoxemic mice. All data were shown as mean ± S.E. NS, no significance