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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Fig. 3

Effects of P2X7R small interfering RNA (siRNA) treatment in ICH rats. RT-PCR of P2X7R after siRNA treatment 24 h following ICH, n = 6 rats per group (a). Western blot assay and quantification of P2X7R (b) after siRNA treatment 24 h following ICH, n = 4 rats per group. Brain edema (c) at 24 h after ICH, n = 6 rats per group. mNSS (d) at 24 and 72 h after ICH, n = 6 rats per group. Data represent means ± SD. ** P < 0.01 vs. Sham, @ P < 0.05 vs. Vehicle, # P < 0.05 vs. ICH + Scramble siRNA. GAPDH glyceraldehyde 3-phosphate dehydrogenase, mNSS modified Neurological Severity Score, siRNA small interfering RNA

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Journal of Neuroinflammation

ISSN: 1742-2094