Skip to main content

Table 2 Change in CES-D score and serum amino acids

From: Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

  Treatment (n = 12) Control (n = 8)
  Baseline 1 month 3 months Baseline 1 month 3 months
CES-D score*** 14.5 ± 10.7 6.8 ± 5.6** 6.5 ± 5.0** 13.9 ± 12.0 11.3 ± 10.3* 14.6 ± 13.6
TRP (μmol/L) 89.2 ± 19.4 87.6 ± 28.8 90.7 ± 26.7 107.8 ± 28.1 105.9 ± 20.3 102.6 ± 14.4
Tyrosine (μmol/L) 48.2 ± 17.7 50.5 ± 15.1 41.5 ± 15.2 59.4 ± 17.6 53.7 ± 15.7 62.2 ± 18.3
Phenylalanine (μmol/L) 36.6 ± 13.6 36.8 ± 13.6 33.6 ± 14.8 42.0 ± 16.6 40.8 ± 18.2 46.2 ± 23.4
BCAA (μmol/L) 700.2 ± 462.4 651.3 ± 351.9 467.9 ± 198.5 449.7 ± 105.5 472.2 ± 112.1 534.3 ± 159.2
LNAA (μmol/L) 785.0 ± 468.2 738.6 ± 352.3 543.1 ± 217.3 551.2 ± 108.7 566.8 ± 123.8 642.7 ± 190.3
TRP/LNAA*** 146.9 ± 71.3 133.6 ± 52.3 188.7 ± 90.4 206.3 ± 79.6 194.0 ± 51.2 171.2 ± 49.8
KYN (μmol/L) 2.3 ± 0.7 2.3 ± 0.6 2.1 ± 0.4 1.7 ± 0.4 2.1 ± 0.3 2.1 ± 0.4
PHE/TYR 786.8 ± 232.2 738.1 ± 229.5 809.5 ± 180.4 746.6 ± 247.1 751.08 ± 219.1 732.78 ± 267.2
KYN/TRP 27.0 ± 11.6 28.5 ± 10.9 24.0 ± 6.6 16.8 ± 4.9 20.3 ± 4.7 20.6 ± 6.0
  1. LNAA (large neutral amino acids) is the sum of tyrosine, phenylalanine, and BCAA; TRP/LNAA ratio is calculated as TRP/LNAA × 1000; KYN/TRP ratio is calculated as KYN/TRP × 1000; and PHE/TYR ratio is calculated as PHE/TYR × 1000
  2. All results are shown as mean ± SD
  3. *Significantly different from baseline with p value ≤0.05
  4. **Significantly different from baseline with p value ≤0.01
  5. ***Significant group × time interaction with p value ≤0.05