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Table 3 Change in inflammatory mediators

From: Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial

  Treatment (n = 12) Control (n = 8)
  Baseline 1 month 3 months Baseline 1 month 3 months
Pro-inflammatory cytokines
 CRP (ng/ml) 4474.7 ± 3578.9 3822.6 ± 3749.4 2865.0 ± 2684.9 2388.1 ± 2928.1 3074.0 ± 3026.4 2458.8 ± 3678.9
 IL-2 (pg/ml) 21.3 ± 51.2 15.1 ± 41.7 17.2 ± 42.1 1.7 ± 3.4 2.9 ± 3.6 2.3 ± 3.3
 IL-6 (pg/ml) 13.9 ± 28.2 9.2 ± 21.3 9.5 ± 19.3 9.0 ± 10.5 13.8 ± 21.2 13.5 ± 21.9
 IL-1β (pg/ml)** 0.9 ± 1.1 0.3 ± 0.3* 0.3 ± 0.2 0.3 ± 0.3 0.4 ± 0.5 0.3 ± 0.2
 TNF-α (pg/ml) 12.5 ± 3.6 11.8 ± 5.5 11.2 ± 4.1 9.8 ± 3.9 11.3 ± 6.7 12.9 ± 10.3
 IFN-γ (pg/ml)** 52.9 ± 94.0 31.9 ± 57.5 35.0 ± 68.4 28.1 ± 46.8 48.8 ± 84.6 49.6 ± 95.3
Anti-inflammatory cytokines
 IL-4 (pg/ml) 7.5 ± 20.8 12.4 ± 23.9 16.2 ± 38.4 19.8 ± 37.2 37.4 ± 83.8 23.8 ± 46.3
 IL-10 (pg/ml) 6.5 ± 12.9 11.2 ± 29.7 9.3 ± 22.0 5.9 ± 14.4 5.7 ± 13.7 6.3 ± 14.6
 IL-1RA (pg/ml) 33.1 ± 26.2 27.8 ± 18.6 26.3 ± 16.0 60.6 ± 66.6 77.2 ± 77.2 78.8 ± 105.8
  1. Pro-inflammatory cytokines consist of a composite score averaging IL-2, IL-6, IL-1β, TNF-α, and IFN-γ; anti-inflammatory cytokines consist of a composite score averaging IL-4, IL-10, and IL-1RA
  2. All results are shown as mean ± SD
  3. *Significantly different from baseline with p value ≤0.05
  4. **Significant group × time interaction with p value ≤0.05