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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Self-reactive CD4+ T cells activated during viral-induced demyelination do not prevent clinical recovery

Fig. 5

Myelin debris within CNS cells. a PLP (red) and Iba1 (green) stainings on spinal cord tissue isolated from Wt-infected mice at day 21 p.i. and analyzed by confocal microscopy. Scale bar, 10 μm. (i) 3D reconstruction image view, yz (ii), and xz (iii) projections show PLP+ myelin in close contact and engulfed (arrow head) by Iba1+ cells. b Percentage of CD45hiCD11b+ and microglia (CD45lowCD11b+) containing GFP between days 7 and 30 p.i. during infection of PLPGFP mice. c Mean GFP fluorescent intensity (MFI) analyzed by flow cytometry in CNS-infiltrating CD45hiCD11b and CD45hiCD11b+ cells and microglia (CD45lowCD11b+) between days 0 to 30 p.i. Hashed bars represent microglia auto-fluorescence detected within infected Wt mice between days 7 and 30 p.i. Data represent the mean ± SEM from two separate experiments with n = 3 per time point per experiment

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