Fig. 4

Deletion of Ifnb in mice decreases spleen weight and number of splenocytes under control conditions, but it prevents a stroke-induced reduction in splenocytes 8 days after tMCAo. a Spleen weight (g) 8 days after tMCAo (WT, n = 7; IFN-βKO, n = 8) and sham surgery (n = 4 for each genotype). b Representative photographs of spleens of sham-operated WT and IFN-βKO mice; photographs were acquired using a MicroPublisher 3.3 RTV CCD camera (QImaging, Surrey, BC, Canada), under standard conditions. c Spleen weight/body weight (ratio). d Corresponding number of splenocytes following occlusion (WT, n = 5; IFN-βKO, n = 6) and sham surgery (n = 4 for each genotype). *p < 0.05 and **p < 0.01 (Bonferroni correction)