Fig. 7
Mice lacking IFN-β show a reduction in grip strength 2 days after tMCAo. a–h IFN-βKO mice. i–k IFNAR-KO mice. a–b Grip strength (in percentage of baseline) 2 and 7 days after tMCAo (WT, n = 6–7; IFN-βKO, n = 8) and sham surgery (n = 4 for each genotype). c Composite neuroscore (0–32) 24 h after tMCAo (WT, n = 19; IFN-βKO, n = 16). d–e Rotating pole scores, referent to 10 rpm to the left, 2 and 7 days after tMCAo. Here, we present individual data points and the median (blue line). f Infarct volume (in mm3) 2 days after tMCAo (n = 5 for each genotype) and g 8 days after tMCAo (WT, n = 7; IFN-βKO, n = 8). h Infarct volume (in mm3) 2 days after pMCAo (n = 5 for each genotype). i Grip strength (g) for the right (R) and left (L) paws 2 days after tMCAo (WT, n = 7; IFNAR-KO, n = 8). j Infarct volumes at 2 days after tMCAo (WT, n = 6; IFNAR-KO, n = 8) and k 24 h after pMCAo (WT, n = 10; IFNAR-KO, n = 9). *p < 0.05 and **p < 0.01 (Bonferroni correction)