Fig. 6

CCR5, CCR2, and CD137 expression on DRG satellite cells. The number of CCR5 (a–c), CCR2 (d–f), and CD137 (g–i) positive satellite cells in DRG tissue was determined by immunohistochemistry in uninfected (a, d, g) and SIV-infected animals (b, e, h). Arrows show CCR5+ cells in SIV+ DRG tissue. For each animal, eight non-overlapping fields of view at ×200 magnification were quantified by manually counting the number of positive cells in the field and dividing by the total area of DRG tissue. The average number of positive cells per square millimeter is plotted for each animal (c, f, i). Analysis in SIV− and SIV+ DRG tissue was determined using a Mann-Whitney test. SIV+ DRGs were grouped according to the tissue pathology. Differences between pathology groups determined using a Kruskal-Wallis test, followed by a Dunn’s post-test. p value of <0.05 was considered significant