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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Fig. 4

PROG treatment mitigates corpus callosum injury after rFPI. As shown in the representative fractional anisotropy (FA) maps (a–d), rFPI + VEH rats had significantly reduced mean FA in the corpus callosum (e) compared to all other groups, whereas the rFPI + PROG group did not significantly differ from SHAM groups. f PROG-treated rats had decreased mean diffusivity in the ipsilateral and contralateral corpus callosum, whereas rFPI rats had increased mean diffusivity in the ipsilateral and contralateral corpus callosum. g PROG-treated rats had decreased radial diffusivity in the ipsilateral and contralateral corpus callosum, whereas rFPI rats had increased radial diffusivity in the ipsilateral and contralateral corpus callosum. h PROG-treated rats had decreased axial diffusivity in the ipsilateral corpus callosum, whereas rFPI rats had increased axial diffusivity in the ipsilateral and contralateral corpus callosum. Triple asterisks significantly different than all other group, number sign significant treatment effect, single asterisk significant injury effect, p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094