Fig. 5From: Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injuryPROG treatment reduces neuroinflammation and oxidative stress after rFPI. As shown in the representative images of GFAP (a–d) and CD68 (e–h) immunofluorescence staining, rFPI + VEH rats had significantly increased GFAP immunoreactive area (i) and CD68-positive cells (j), whereas the rFPI + PROG group did not significantly differ from SHAM groups on either measure. The rFPI + VEH rats also showed significantly increased levels of MDA, a marker of lipid peroxidation, compared to all other groups (k). Though rFPI + PROG rats had significantly less lipid peroxidation than rFPI + VEH rats, they had significantly more lipid peroxidation than both SHAM groups. Triple asterisks significantly different than all other groups, double asterisks significantly different than SHAM groups, p < 0.05Back to article page