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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

Fig. 1

FTY720 treatment increases TCF7 expression in T cells. a Heatmap showing significantly changing mRNA expression upon CD4 naïve T cell activation in the presence or absence of FTY720 as measured by a nanostring array of 500 immune genes. b Expression of TCF7 in in vitro activated T cells from healthy control (HC) individuals in the presence (T-FTY720) or absence (T-CTL) of FTY720 analyzed using nanostring (n = 6). c Expression of TCF7 in in vitro activated T cells from HC individuals in the presence or absence of FTY720 analyzed using qPCR (n = 10). **p < 0.01, paired non-parametric t tests

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