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Table 1 Effect of dexamethasone and meloxicam on cytokines and chemokines induced by live Bb in HSC

From: Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system

Immune mediator

HSC medium control

HSC + live Bb (10:1)

HSC + live Bb + dexamethasone (150 μM)

HSC + live Bb + meloxicam (100 μM)

IL-1RA

31.38 ± 0.97

84.76 ± 9.75

18.10 ± 0.97

130.09 ± 29.18

p < 0.001

p < 0.05

IL-6

266.62 ± 12.75

1420.76 ± 62.98

850.96 ± 19.09

1845.76 ± 23.87

p < 0.001

p < 0.001

IL-8

1930.90 ± 129.43

10297.62 ± 759.93

3093.81 ± 198.68

13,686.96 ± 494.18

p < 0.001

p < 0.001

IL-10

34.86 ± 1.45

89.11 ± 2.23

110.68 ± 2.08

92.04 ± 11.43

p < 0.001

ns

IL-12 p70

303.45 ± 21.69

658.21 ± 29.69

367.02 ± 15.02

767.67 ± 36.3

p < 0.001

p < 0.05

IL-15

6.56 ± 0.58

23.67 ± 2.54

11.42 ± 1.34

38.49 ± 3.82

p < 0.001

p < 0.001

CCL2/MCP-1

885.83 ± 51.57

3227.74 ± 153.35

835.10 ± 25.57

4719.75 ± 212.96

p < 0.001

p < 0.001

CCL-5/RANTES

3.65 ± 0.7

38.19 ± 3.79

8.49 ± 1.79

47.99 ± 3.76

p < 0.001

p < 0.01

PDGF

5.65 ± 1.04

37.84 ± 4.07

14.69 ± 1.74

40.38 ± 3.47

p < 0.001

ns

IFN-γ

34.95 ± 5.48

86.33 ± 9.31

38.59 ± 3.54

112.06 ± 15.18

p < 0.001

ns

IP-10

18.94 ± 2.75

856.47 ± 73.95

365.94 ± 24.53

853.49 ± 52.38

p < 0.001

ns

G-CSF

511.26 ± 56.98

3032.42 ± 116.01

1725.49 ± 65.32

3410.18 ± 97.08

p < 0.001

p < 0.05

VEGF

1088.41 ± 162.82

5925.06 ± 195.08

2920.06 ± 130.67

6943.79 ± 172.48

p < 0.001

p < 0.001

TNF

5.24 ± 0.9

22.22 ± 2.79

8.15 ± 1.87

24.02 ± 2.69

p < 0.001

ns

  1. Cytokines and chemokines in HSC culture supernatants after 48 h of incubation with live Bb (MOI 10:1). Data represent mean (pg/ml) and SD of triplicate evaluations (p values represent significance for comparisons of values for Bb and Bb + Dex 150 μM or Bb and Bb + Mel 100 μM and ns not significant)