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Table 1 Effect of dexamethasone and meloxicam on cytokines and chemokines induced by live Bb in HSC

From: Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system

Immune mediator HSC medium control HSC + live Bb (10:1) HSC + live Bb + dexamethasone (150 μM) HSC + live Bb + meloxicam (100 μM)
IL-1RA 31.38 ± 0.97 84.76 ± 9.75 18.10 ± 0.97 130.09 ± 29.18
p < 0.001 p < 0.05
IL-6 266.62 ± 12.75 1420.76 ± 62.98 850.96 ± 19.09 1845.76 ± 23.87
p < 0.001 p < 0.001
IL-8 1930.90 ± 129.43 10297.62 ± 759.93 3093.81 ± 198.68 13,686.96 ± 494.18
p < 0.001 p < 0.001
IL-10 34.86 ± 1.45 89.11 ± 2.23 110.68 ± 2.08 92.04 ± 11.43
p < 0.001 ns
IL-12 p70 303.45 ± 21.69 658.21 ± 29.69 367.02 ± 15.02 767.67 ± 36.3
p < 0.001 p < 0.05
IL-15 6.56 ± 0.58 23.67 ± 2.54 11.42 ± 1.34 38.49 ± 3.82
p < 0.001 p < 0.001
CCL2/MCP-1 885.83 ± 51.57 3227.74 ± 153.35 835.10 ± 25.57 4719.75 ± 212.96
p < 0.001 p < 0.001
CCL-5/RANTES 3.65 ± 0.7 38.19 ± 3.79 8.49 ± 1.79 47.99 ± 3.76
p < 0.001 p < 0.01
PDGF 5.65 ± 1.04 37.84 ± 4.07 14.69 ± 1.74 40.38 ± 3.47
p < 0.001 ns
IFN-γ 34.95 ± 5.48 86.33 ± 9.31 38.59 ± 3.54 112.06 ± 15.18
p < 0.001 ns
IP-10 18.94 ± 2.75 856.47 ± 73.95 365.94 ± 24.53 853.49 ± 52.38
p < 0.001 ns
G-CSF 511.26 ± 56.98 3032.42 ± 116.01 1725.49 ± 65.32 3410.18 ± 97.08
p < 0.001 p < 0.05
VEGF 1088.41 ± 162.82 5925.06 ± 195.08 2920.06 ± 130.67 6943.79 ± 172.48
p < 0.001 p < 0.001
TNF 5.24 ± 0.9 22.22 ± 2.79 8.15 ± 1.87 24.02 ± 2.69
p < 0.001 ns
  1. Cytokines and chemokines in HSC culture supernatants after 48 h of incubation with live Bb (MOI 10:1). Data represent mean (pg/ml) and SD of triplicate evaluations (p values represent significance for comparisons of values for Bb and Bb + Dex 150 μM or Bb and Bb + Mel 100 μM and ns not significant)