Fig. 6
From: Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
Effect of CK2 inhibitors on IL-6 and MCP-1 secretion. U373 cells and human primary astrocytes were stimulated with either IL-1β (10 U/ml) or TNF-α (100 ng/ml) for 24 h in the absence or presence of different concentrations of CX-4945 (a) or TBB (b). IL-6 and MCP-1 levels in the culture supernatants were determined by ELISA. The stars indicate significant difference (p value <.05) between the condition without inhibitor, labelled with 0 μM, and the corresponding condition with either 1, 5 or 10 μM CX-4945 (a–d) or 1, 5, 20 μM TBB (e–h)