Fig. 2
From: Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
Effect of MEK, MAPK or IKK inhibitors on the protein levels of mPGES-1 and COX-2 at 24 and 48 h after stimulation with poly(I:C) in microglia. a, b Effect of PD98059 and SB203580 (MEK and p38 MAPK inhibitors, respectively (a)) and SP600125 and SC514 (JNK and IKK2 inhibitors, respectively (b)) on the protein levels of mPGES-1, COX-2, and actin 24 h after poly(I:C) stimulation. c, e Effect of PD98059, SB203580, SP600125, SC514, and PD0325901 (MEK inhibitor) on the protein levels of mPGES-1, COX-2, and actin levels 48 h after poly(I:C) stimulation. d, f Immunoblot analysis of protein levels of COX-2, mPGES-1, and actin in poly(I:C)-activated microglia 48 h after stimulation. *P < 0.05 and ***P < 0.001 in comparison with the respective poly(I:C) control