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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CXCL5 signaling is a shared pathway of neuroinflammation and blood–brain barrier injury contributing to white matter injury in the immature brain

Fig. 2

LPS-sensitized HI induced microglial activation and BBB damage. Neuroinflammation and BBB damage were assessed 24 h after insult. The LPS + HI group had a significantly higher number of ED1(+) activated microglia (upper panel) and significantly greater IgG extravasation suggesting BBB damage (middle panel) but fewer MPO(+) neutrophils (lower panel) in the white matter than did the control group (n = 6 in each group). BBB, blood–brain barrier. Scale bar = 50 μm (ED1) and = 100 μm (IgG and MPO). Values are means ± SEMs, **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094