Fig. 1

The effects bvPLA2 on the body weights and behaviors of the 3xTg mice. The body weight curves for the different groups of experimental animals were determined (a). WT PBS-treated wild type group, 3xTg 3xTg group, donepezil donepezil-treated 3xTg group, bvPLA2 0.2 bvPLA2 0.2 mg/kg-treated 3xTg group, 3xTg+bvPLA2 bvPLA2 1 mg/kg-treated 3xTg group. The latencies to escape onto the hidden platform in the Morris water maze. The task was performed for three trials per day over 4 days for the acquisition test (b). Retention performance was tested on fourth day. In the retention test, the mice received a probe trial in which the platform was removed from the pool (c). The values are presented as the means ± the SEMs. *P < 0.05, **P < 0.01, compared to the WT group; #P < 0.05, compared to the 3xTg group (repeated-measures ANOVA with and Tukey’s post hoc analyses)