Fig. 5

Effects of U0126, apocynin, or p47phox knockout on mitochondrial translocation of cleaved PKCδ after MA. Mitochondrial translocation of cleaved PKCδ after MA (35 mg/kg, i.p.) treatment (a) and effects of U0126, apocynin, or p47phox knockout on mitochondrial translocation of cleaved PKCδ (b). WT wild-type mice, p47 KO p47phox knockout mice, Sal saline, U U0126 (2 μg, i.c.v.), Apo apocynin (50 mg/kg, i.p.), V or Veh vehicle [10 % (v/v) DMSO] for U0126 or apocynin. Each value is the mean ± S.E.M. of six animals. ^** P < 0.01 vs. saline. ^& P < 0.001 vs. vehicle/WT with saline. ^## P < 0.01 vs. vehicle/WT with MA [one-way ANOVA (a) or three-way ANOVA (b) was followed by Fisher’s LSD pairwise comparisons]