Myeloid dendritic cells are decreased in peripheral blood of Alzheimer’s disease patients in association with disease progression and severity of depressive symptoms

Table 1 Demographic and clinical characteristics of HC, MCI, and AD subjects

	HC	MCI	AD	AD w/o AChEI	AD AChEI
n	73	65	106	40	66
Gender (female, %)	57.2	57.0	51.9	55.0	50.0
Age (years)	71.5 ± 0.5	71.2 ± 0.7	72.1 ± 0.6	72.3 ± 1.0	71.9 ± 0.8
Education (years)	11.3 ± 0.5	9.0 ± 0.5*	8.5 ± 0.5**	9.0 ± 0.7*	8.1 ± 0.7**
MMSE	28.6 ± 0.1	27.0 ± 0.2**	20.9 ± 0.4**	22.0 ± 0.6**	20.0 ± 0.6**
ADL	5.9 ± 0.3	6.1 ± 0.05	8.5 ± 0.3**	8.0 ± 0.3**	8.9 ± 0.5**
IADL	6.7 ± 0.2	7.2 ± 0.2	13.8 ± 0.6**	12.9 ± 0.8**	14.6 ± 0.8**
NPI dep. (F × S)	1.3 ± 0.2	2.1 ± 0.2*	3.0 ± 0.2**	3.4 ± 0.4**	2.7 ± 0.3**

Data are expressed as mean ± SEM; *p < 0.005 and **p < 0.0005 vs HC
MMSE mini-mental status examination, ADL activities of daily living, IADL instrumental activities of daily living, NPI dep. (F × S) neuropsychiatric inventory–depression (frequency × severity)

ISSN: 1742-2094