Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases

Table 1 IC₅₀ (μM) based on stimulated glial cell-released TNFα and IL-6 data of NaSH and STS at 8 h pre-incubation times

(A) TNFα: THP-1 cells and microglia
	THP-1 cells		Microglia
Pre-incubation time	NaSH	STS	NaSH	STS
8 h	31.15 ± 3.66	424.53 ± 18.25*	26.71 ± 4.32	579.53 ± 27.75*
(B) IL-6: THP-1 cells and microglia
	THP-1 cells		Microglia
Pre-incubation time	NaSH	STS	NaSH	STS
8 h	63.84 ± 7.95	621.53 ± 24.25*	33.36 ± 5.32	87.28 ± 6.79*
(C) IL-6: U373 cells and astrocytes
	U373 cells		Astrocytes
Pre-incubation time	NaSH	STS	NaSH	STS
8 h	432.26 ± 54.14	1356.53 ± 224.25*	7.44 ± 0.87	102.79 ± 11.25*

The tables summarized the IC₅₀ results of the studies in Fig. 3 (Table 1 (A, B)) and Fig. 4 (Table 1 (C)). Values are mean ± SEM, n = 4. One-way ANOVA was carried out to test significance. Note that there was a significant reduction in IC₅₀ values of NaSH compared with those of STS in all groups
*P < 0.01

ISSN: 1742-2094