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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

Fig. 4

RGS10-null lymphocytes displayed attenuated recall response to MOG35–55. WT and RGS10-null mice were immunized with MOG35–55 as described in the “Methods” section. Ten days later, (a) lymph node cells or (b) splenocytes were isolated and re-stimulated ex vivo with the indicated concentrations of MOG35–55 peptide for 72 h. Proliferation was assessed via MTS incorporation assay. c After 72 h, cytokine secretion by WT and RGS10-null MOG35–55-re-stimulated lymph node cells was determined by MSD assay. **p < 0.01, ***p < 0.001, two-way ANOVA with Bonferroni post hoc test (n = 3–4 mice per group)

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