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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

Fig. 1

IHC analysis of immune cell markers in eGFP chimeras at 6 months following brain irradiation. To determine if the radiation component of chimera induction altered the presence of immune markers seen following brain irradiation in wild-type animals, 0- and 35-Gy brain-irradiated eGFP chimera (bone marrow transplant: eGFP-BMT) and non-chimera (Non-Trans) animals were analyzed for a MHCII+, b CD3+, and c CD11c+ cells at 6 months post-irradiation. The numbers of positively stained cells quantified in the first two sections containing the dentate gyrus as described in the Methods section were compared using a two-way ANOVA with Fisher’s protected least significant (PLSD) post hoc tests comparing all conditions. Graph bars represent mean ± SEM, n = 4–6 mice per condition: **p ≤ 0.01 and ***p ≤ 0.001

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