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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

Fig. 2

Fc is not required for the protective effect of IVIG. a Coomassie® Brilliant Blue stained non-reducing (left) or reducing (right) SDS-PAGE showing IVIG and purified F(ab’)2. B6 mice were immunized with MOG35–55 peptide emulsified in CFA and injected i.p. with IVIG, F(ab’)2, or buffer starting 1 day before immunization. Disease severity (b) and incidence (c) are shown. n = 12 animals per group. Individual curves in (b) were compared to buffer treated animals using two-way ANOVA and Bonferroni posttest. ***p ≤ 0.001

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