Fig. 5

TNF blockade restores BBB integrity during progressive EAE. a BBB integrity in brains and spinal cords determined by sodium fluorescein permeability assay determined at day 25 p.i. in WT and GFAPγR1∆ mice treated with α-TNF or control mAb. Data is represented as fold increase over naïve values with six mice per group. b Confocal images (Z-stack, magnification ×40) of spinal cords stained with laminin (green), IgG (red), and DAPI (blue) at d30 p.i. Images representative of two individual mice per group. P values determined by Student’s t test