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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

Fig. 7

Tau phosphorylation in primary neurons were promoted by the CM from Nogo/NgR-activated BV-2 microglia. Neurons were exposed to the CM of BV-2 microglia at different stimulations for 24 h. The expression of tau (a, b) was determined using western blot. Values were reported as mean ± SD, as a percentage of values determined in the PBS group (control, 100 %). Effects of CM from Nogo/NgR pathway activated BV-2 microglia on tau phosphorylation (c–e) and GSK-3β activation (f, g) in primary neurons were measured using western blot. Values were reported as mean ± SD. *p < 0.05, **p < 0.01, n = 3

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Journal of Neuroinflammation

ISSN: 1742-2094