Fig. 9

Inhibition of the Nogo/NgR pathway improved neuroinflammatory environment in APP/PS1 mice. Homogenates from brain tissue of 8-month-old APP/PS1 transgenic mice were subjected to western blot to measure the expression of COX-2 and iNOS. a, b COX-2. d, e iNOS. Values were reported as mean ± SD, as a percentage of values determined in the vehicle group (control, 100 %). The brain of APP/PS1 mice was homogenized, and the proportions of IL-1β (g) and IL-4 (q) were determined using ELISA. Values were reported as mean ± SD. Inflammatory gene transcripts in the brain from 8-month-old APP/PS1 mice were measured by quantitative RT-PCR. c COX-2. f iNOS. h IL-1β. i TNF-α. j IL-6. k CCL2. l Arg1. m Fizz1. n Ym1. o cd206. p IL-10. r IL-4. Values were reported as mean ± SD, as a percentage of values determined in the vehicle group (control, 100 %). *p < 0.05; **p < 0.01; ***p < 0.001, when compared with the vehicle group, n = 3–6