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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

Fig. 1

Brain PDGFRβ+ PCs express Iba1 following ischemia. At the ischemic site, PDGFRβ+ expression was specifically observed in PCs located near CD31+ endothelial cells (PDGFRβ (a, b green), CD31 (a, b red), DAPI (a, b blue)). On day 3 post-stroke, only a few PDGFRβ+ iPCs expressed Iba1 (cf) (PDGFRβ (d, e red), Iba1 (d, f green), DAPI (df blue)) (arrow). However, some Iba1+PDGFRβ+ iPCs were observed in the ischemic areas on post-stroke day 5 (gk) (PDGFRβ (h, i, k: red), Iba1 (h, j, k green), DAPI (hk blue)) (arrows). The numbers of Iba1+ and PDGFRβ+ cells (l) and populations of Iba1+ cells relative to those of the PDGFRβ+ cells (m) localized to the ischemic core and peri-ischemic areas are shown. Scale bars = 100 μm (a), 50 μm (b), and 20 μm (d, h, k). Iba1 ionized calcium binding adaptor molecule 1, PDGFRβ platelet-derived growth factor receptor-β

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