Fig. 2

JhD/MRL/lpr and hCD20-DTA/MRL/lpr mice display depression-like behavior and cognitive dysfunction. The Porsolt swim test (a) was performed to evaluate behavioral despair in JhD/MRL/lpr and hCD20-DTA/MRL/lpr mice. (Left panels: LPR mice, n = 10; JhD mice, n = 17; MPJ mice n = 4; Right panels: LPR mice, n = 7; hCD20-DTA mice, n = 7; MPJ mice, n = 12). Object placement (b) and object recognition (c) tests were employed to assess cognitive function in JhD/MRL/lpr and hCD20-DTA/MRL/lpr mice. The dotted line indicates 53 % preference score. (Left panels: LPR mice, n = 5; JhD mice, n = 5; MPJ mice n = 5; Right panels: LPR mice, n = 7; hCD20-DTA mice, n = 7; MPJ mice, n = 10–11). Since testing affects subsequent performance in neurobehavioral analysis, all behavior tests in a–c were only conducted once. The JhD/MRL/lpr mice were tested at 7–12 weeks of age, and hCD20-DTA/MRL/lpr mice at 16–18 weeks of age. The control MRL/lpr and MRL/MPJ mice used for comparison were separately age matched to the JhD/MRL/lpr and hCD20-DTA/MRL/lpr strains, respectively