Fig. 3

JhD/MRL/lpr mice exhibit increased general locomotor activity. General locomotor activity was assessed by open field test in JhD/MRL/lpr at 7–12 weeks of age and hCD20-DTA/MRL/lpr mice at 16 weeks of age including measurement of a total track length, b rears, c center track length (in cm), d center time (in seconds (s)), and e relative center track length (center track length/total track length). (Left panels: LPR mice, n = 11; JhD mice, n = 11–12; MPJ mice, n = 5–8; Right panels: LPR mice, n = 7; hCD20-DTA mice, n = 7; MPJ mice, n = 7–17). Open field tests were conducted once. The control MRL/lpr and MRL/MPJ mice used for comparison were separately age matched to the JhD/MRL/lpr and hCD20-DTA/MRL/lpr strains, respectively