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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Fig. 2

ALX/FPR2 receptor gene knockdown with intrathecal siRNA treatment impairs the analgesic effect of LXA4 after SCI in mice. a No differences were observed on the 7th day post-surgery with the siRNA administration in the ipsilateral paw. b Gene knockdown suppresses the antihyperalgesic effects of LXA4 observed in the contralateral paw. c On the 7th day after surgery, there is a significant decrease on ALX/FPR2 receptor mRNA levels in the spinal cord of animals injected with the specific siRNA. Results are presented as mean ± SEM. Asterisk denotes p < 0.05 when comparing to control-siRNA-treated group (two-way ANOVA followed by Bonferroni, n = 6 mice/group)

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Journal of Neuroinflammation

ISSN: 1742-2094