Fig. 5
The number of infiltrating leukocytes is decreased in APRIL KO mice 1 week following SCI. The number of infiltrating macrophages (CD45hiCD11b+) and B cells (B220+) were significantly reduced following SCI in APRIL KO mice (n = 7) compared to WT controls (n = 10) (a). This translated to a reduction in the overall number of infiltrating leukocytes (b), whereas the number of microglia remained similar between WT and KO mice (c). However, the percentages of each cell type, including microglia, were not different (d–f). n = biological replicates. *p < 0.05 compared to WT. Student’s t test