Fig. 3

Representative images of macrophages activation in longitudinal sections of the proximal and distal stumps of sciatic nerve. Immunolabeling was performed in C3H/HePas and C3H/HeJ mice at 3 (a–d), 7 (e–h) and 14 (i–l) days after nerve crush, times that correspond to key steps in the remyelination process. (m–o) Graphs of the integrated density of pixels of activated macrophages under an equivalent area for all groups. Note that the absence of TLR4 did not influence the recruitment of macrophages to the lesion site at any time analyzed. Scale bar: 30 μm