Fig. 1
Seipin deficiency enhances Aβ25–35-induced cognitive deficits. a The latencies (s) to reach the visible and hidden platforms (upper panel) and the swimming speeds (m/s, bottom panel) of WT mice (WT), Aβ25–35 mice (Aβ), seipin-KO mice (KO), and Aβ25–35-KO mice (KO/Aβ) in the Morris water maze (MWM) test. The left panels illustrate representative swimming tracks of the mice searching for the underwater platform on day 5 after training. The black dots indicate the position of the hidden platform. **P < 0.01 vs. WT mice; ## P < 0.01 vs. seipin-KO mice (repeated-measures ANOVA with Bonferroni’s test). b The bars represent the percentages of time spent in the target quadrant (TQ), opposite quadrant (OQ), and right (R) and left (L) adjacent quadrants (AQ) of the probe test. The left panels illustrate typical tracks. **P < 0.01 vs. WT mice; ## P < 0.01 vs. seipin-KO mice (two-way ANOVA with Bonferroni’s test). c, d The bar graphs display group means in the alternation rate (%) and the numbers of arm entries (8 min) in the Y-maze (Y-M) task. *P < 0.05 and **P < 0.01 vs. WT mice; # P < 0.05 vs. seipin-KO mice (two-way ANOVA with Bonferroni’s test)