Fig. 2

Activation of PPARγ prevents enhanced Aβ_25–35-induced cognitive deficits by seipin deficiency. a The bars indicate the densitometric values of the hippocampal PPARγ protein in WT mice (WT), Aβ_25–35 mice (Aβ), seipin-KO mice (KO), and Aβ_25–35-KO mice (KO/Aβ). *P < 0.05 vs. WT mice (two-way ANOVA with Bonferroni’s test). b Time chart of the experimental procedure. MWM Morris water maze task, Y-M Y-maze task. c -i and c- ii Each point represents the group mean latency (s) to reach the visible and hidden platforms in WT mice, vehicle-treated seipin-KO mice (KO), rosi-treated seipin-KO mice (KO/rosi), Aβ_25–35-KO mice (KO/Aβ), and Aβ_25–35-KO mice (KO/Aβ/rosi). *P < 0.05 and **P < 0.01 vs. WT mice; ^# P < 0.05 and ^## P < 0.01 vs. seipin-KO mice; ⁺⁺ P < 0.01 vs. KO/Aβ mice (repeated-measures ANOVA with Bonferroni’s test). d The bars represent the percentages of time spent in a target quadrant of the probe test. *P < 0.05 and **P < 0.01 vs. WT mice; ^# P < 0.05 vs. seipin-KO mice; ⁺⁺ P < 0.01 vs. KO/Aβ mice (two-way ANOVA with Bonferroni’s test). e Bar graph indicates the alternation rates (%) in the Y-maze task. *P < 0.05 vs. WT mice; ^# P < 0.05 vs. seipin-KO mice; ⁺ P < 0.05 vs. KO/Aβ mice (two-way ANOVA with Bonferroni’s test)