Microglial immunophenotype in dementia with Alzheimer’s pathology

Table 5 Weighted linear regression analyses investigating the relationship between microglial protein load (%) and the MMSE score in participants with and without dementia

Microglia (load (%))	No dementia			Dementia with Alzheimer’s pathology
Microglia (load (%))	β	95 % CI (β)	P	β	95 % CI (β)	P
Iba1	0.37	(0.29; 0.45)	<0.001	−0.13	(−0.32; 0.05)	0.154
CD68	−1.54	(−2.96;−0.13)	0.033	−12.17	(−15.13; −9.21)	<0.001
HLA-DR	0.18	(−0.04; 0.41)	0.116	−1.11	(−1.59; −0.64)	<0.001
MSR-A	−0.69	(−1.38; 0.00)	0.051	−4.94	(−6.82; −3.07)	<0.001
CD64	0.27	(−0.03; 0.58)	0.076	1.08	(0.15; 2.02)	0.023

These analyses only included participants without dementia or with dementia with Alzheimer’s pathology. Significant positive association (bold); significant negative association (italic)

ISSN: 1742-2094