Fig. 3

Neutralizing CCL20 improves histopathological outcome in the injured spinal cord. a H&E staining of the spinal cord sections at 28 days post-SCI shows varying sizes of the cystic cavity, inflammatory cell infiltration, and formation of a glial scar around the cavity. Scale bar = 1 mm. b, c Quantitative data of lesion tissue and spared tissue shows a significantly decreased lesion volume and increased spared tissue area, respectively, in CCL20 mAb-treated rats at the injury epicenter and both rostral and caudal directions, respectively. ⁺ P < 0.05, compared with the sham group; ^* P < 0.05, compared with the CCL20 mAb group; &P < 0.05, compared with the isotype control group