Fig. 8

Th17 cells are recruited by CCL20 post-SCI. a Th17 cells from the spinal cord at 14 days post-injury were initially targeted by CD3⁺ T cells from isolated lymphocytes. b The isotype control from the IL-17A-PE staining. c CD8⁻ IL-17A⁺ cells represent Th17 cells. d The frequency of Th17 cell was significantly reduced by application of CCL20 mAb, indicating that CCL20 blockade directly decreases Th17 cell recruitment in the spinal cord. ⁺ P < 0.05, compared with the sham group; ^* P < 0.05, compared with the CCL20 mAb group