Fig. 1

Scheme of animal study design. a For contusion volume (or lesion) and behavioral analyses, animals were submitted to TBI or a sham procedure at time zero; thereafter, they were dosed with either vehicle (veh) or pomalidomide (Pom) at either 5 or 7 h later. Behavioral analyses were performed after 24 h, and thereafter, animals were euthanized for evaluation of contusion volume. b For morphological evaluation of neurodegeneration and apoptosis or biochemical measurement of cytokine mRNA and protein levels, animals were subjected to TBI or a sham procedure at time zero; thereafter, they were dosed with either vehicle (veh) or pomalidomide (Pom) at 5 h and were euthanized at either 8 or 24 h. For each group, n = 5