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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

Fig. 4

Pom administered at 5 h post-injury improved functional outcomes as revealed by behavioral evaluation at 24 h after TBI. a Motor asymmetry measured by elevated body swing test (EBST). TBI-induced deficits were attenuated by Pom (0.5 mg/kg). b Motor coordination and balance measured by beam walking test. TBI impairments were attenuated by Pom (0.5 mg/kg). c Animals treated with Pom (0.5 mg/kg), overall presented with better neurological severity scores (mNSS), as indicated in the animal groups scores shown in (c). TBI induced abnormalities in sensory/motor function that were revealed by a longer latency for the animals to remove an adhesive sticker from their contralateral (c) but not ipsilateral (I) forepaw. Treatment with Pom (0.5 mg/kg) significantly attenuated this behavioral deficit. Data represent the mean ± S.E.M. (n = 5 in each group). *p < 0.05, ***p < 0.001 versus sham group; # p < 0.05, ### p < 0.001 versus TBI + Veh group; +++ p < 0.001 versus non-impaired left

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