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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease

Fig. 4

Long-term THP treatment recruits distinct gene expression profiles. a Scatterplot of hybridizing signal intensity on DNA microarray. Genetic scatterplot showing differentially regulated hippocampal genes compared with age-matched, NS-treated animals after long-term THP treatment. The X and Y axes represent fluorescence intensities of Cy3 and Cy5 signals, respectively. Every spot corresponds to the cross-fertilization signal of one gene. Red represents upregulation while green shows downregulation. b Gene transcription profiling reveals functional categories regulated by THP in the hippocampus of aging rats, perculair for MHC class I complex with the highest significance as shown in green circle area. And c only one common transcript Lpl correlated with Alzheimer’s disease was found and differentially regulated by THP, but less significantly (P = 0.5843). These functional pathways were derived from KEGG database analyses

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Journal of Neuroinflammation

ISSN: 1742-2094