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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A

Fig. 6

Time course of the onset and offset of desensitization of the PGE2-induced activation of PKA in sensory neuronal cultures after chronic exposure to the eicosanoid. Each column represents the mean ± SEM of PKA activity normalized to total PKA activity for various times of exposure to 1 μM PGE2 or after removal of 1 μM PGE2. a Cultures were pretreated with vehicle (open column) or 1 μM PGE2 (hatched columns) for the times indicated in the time line in the top portion of the figure. b Cultures were pretreated with vehicle (open column) or PGE2 (hatched columns) for the times indicated in the time line in the top portion of the figure, and then, the PGE2 is removed and cells assayed at the times indicated. An asterisk indicates a statistically significant difference between PGE2-treated sensory neuronal cultures and vehicle-treated cultures using one-way ANOVA followed by Bonferroni’s post hoc test

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Journal of Neuroinflammation

ISSN: 1742-2094