Fig. 6
From: The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
URMC-099 facilitates subcellular co-localization of Aβ42 with Rab7 and Lamp1 in murine microglia. Confocal microscopy shows cellular localization of Rab7 late endosomal component (a, red) or Lamp1 lysosomal compartment (b, red) and Aβ42 (green). Merged images of Rab7 and Lamp1 are shown. Aβ42 co-localization with Rab7 (c) or Lamp1 (d) was quantified by ImageJ with a co-localization plugin. Scale bar = 50 μm. Bars represent mean ± SEM. *p < 0.05 by Student’s t test