Table 2 Comparison between expected additive effects and measured effects of TLR ligand interactions in embryonic ENS culture
From: TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide
Cytokine | TLR ligand combination | Expected additive effect (%) | Measured effect (%) | N | P |
|---|---|---|---|---|---|
TNF-α | Pam2CSK4 + LPS | 53.9 ± 8.5 | 52.1 ± 7.8 | 5 | 0.744 |
ODN 1826 + LPS | 51.9 ± 8.5 | 100 ± 20.4 | 5 | 0.02 | |
IL-6 | Pam2CSK4 + LPS | 43.7 ± 5.7 | 45 ± 8.5 | 5 | 0.729 |
ODN 1826 + LPS | 42.3 ± 5.9 | 100 ± 24.8 | 5 | 0.048 | |
MCP-1 | Pam2CSK4 + LPS | 91.5 ± 3.6 | 85.2 ± 5.3 | 5 | 0.102 |
ODN 1826 + LPS | 88.2 ± 4.3 | 100 ± 5.4 | 5 | 0.02 |