Fig. 7

Clogging of the blood vessels by Streptococcus pneumoniae after systemic infection. a–d Confocal microscopy images at maximum projection of Tg(kdrl:mcherry) ^s896 zebrafish embryos at 4 days post- fertilization injected in the caudal vein. a, c Bacteria were localized inside and outside of the blood vessels with (arrows) and without clogging (arrow heads). Scale bars, 100 μm. b, d An enlarged view of a and c, respectively, with clogging of a blood vessel highlighted. All embryos were infected with 600 CFU and imaged at 24 h post injection. Scale bars, 50 μm