Skip to main content

Table 3 Immunoreactivity of β1, β1i, β5, and β5i proteasome subunits in the cortex

From: Dysregulation of the (immuno)proteasome pathway in malformations of cortical development

  

(Dysmorphic) neurons

Glia

Balloon/giant cells

Cytoplasm

Nucleus

Cytoplasm

Nucleus

Cytoplasm

Nucleus

β1

Control

2 (2–3)

0

0 (0–1)

0

mMCD

2▪°~

1 (1–2)*°~

0▪°~

0°~

FCDIIa

5 (4–9)*

1 (1–2)*°

2.5 (2–4)*

2.5 (2–4)*°

FCDIIb

7.5 (3–9)*

6 (3–6)*

4 (3–6)*

5 (4–6)*

3.5 (3–6)

6 (4–9)

TSC

6.5 (4–9)*

5 (4–9)*

7.5 (4–9)*

7.5 (4–9)*

6 (3–9)

9 (6–9)

β1i

Control

0 (0–1)

0 (0–1)

1 (0–1)

0 (0–2)

mMCD

0▪°~

0▪°~

0 (0–1)▪°~

0▪°~

FCDIIa

3 (2–4)*

4 (3–6)*~

3.5 (3–4)*

3 (3–6)*~

FCDIIb

4 (2–4)*

6 (3–9)*

6 (3–9)*

5 (3–6)*

4 (3–4)

7.5 (3–9)

TSC

3.5 (2–6)*

6 (4–9)*

5 (3–9)*

5 (2–9)*

4 (3–6)

7.5 (4–9)

β5

Control

1 (0–1)

1 (0–1)

0

0 (0–1)

mMCD

0°~

6*▪

0°~

0▪°~

FCDIIa

3.5 (2–4)*~

7.5 (6–9)*

1.5 (0–2)*~

2.5 (1–4)*~

FCDIIb

6 (4–6)*°

9 (6–9)*

3.5 (3–4)*

6 (4–9)*°

4 (3–6)

9 (6–9)

TSC

3.5 (3–4)*

7.5 (6–9)*

2.5 (2–4)*

2.5 (2–4)*

6 (4–9)

9 (6–9)

β5i

Control

0

0

0 (0–1)

1 (1–2)

mMCD

0▪~

0 (0–1)°~

0°~

FCDIIa

1.5 (1–4)*

0 (0–2)°

0 (0–2)~

FCDIIb

0 (0–1)°

4 (3–6)°

2.5 (1–3)°

3 (1–6)

0 (0–1)°

6 (4–6)°

TSC

6 (4–9)*

0.5 (0–1)

6 (4–9)*

1.5 (1–2)*

9 (6–9)

0.5 (0–1)

  1. Immunoreactivity score (IRS) is given as median (minimum-maximum). IRS is defined as intensity score multiplied by frequency score (see “Methods” section). Kruskall-Wallis test followed by Mann-Whitney U test
  2. *Different compared to controls; °different compared to TSC; ▪different compared to FCDIIa; ~different compared to FCDIIb, p < 0.05