From: Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
(Dysmorphic) neurons | Glia | Balloon/giant cells | |||||
---|---|---|---|---|---|---|---|
Cytoplasm | Nucleus | Cytoplasm | Nucleus | Cytoplasm | Nucleus | ||
β1 | Control | 2 (2–3) | 0 | 0 (0–1) | 0 | – | – |
mMCD | 2▪°~ | 1 (1–2)*°~ | 0▪°~ | 0°~ | – | – | |
FCDIIa | 5 (4–9)* | 1 (1–2)*° | 2.5 (2–4)* | 2.5 (2–4)*° | – | – | |
FCDIIb | 7.5 (3–9)* | 6 (3–6)* | 4 (3–6)* | 5 (4–6)* | 3.5 (3–6) | 6 (4–9) | |
TSC | 6.5 (4–9)* | 5 (4–9)* | 7.5 (4–9)* | 7.5 (4–9)* | 6 (3–9) | 9 (6–9) | |
β1i | Control | 0 (0–1) | 0 (0–1) | 1 (0–1) | 0 (0–2) | – | – |
mMCD | 0▪°~ | 0▪°~ | 0 (0–1)▪°~ | 0▪°~ | – | – | |
FCDIIa | 3 (2–4)* | 4 (3–6)*~ | 3.5 (3–4)* | 3 (3–6)*~ | – | – | |
FCDIIb | 4 (2–4)* | 6 (3–9)* | 6 (3–9)* | 5 (3–6)* | 4 (3–4) | 7.5 (3–9) | |
TSC | 3.5 (2–6)* | 6 (4–9)* | 5 (3–9)* | 5 (2–9)* | 4 (3–6) | 7.5 (4–9) | |
β5 | Control | 1 (0–1) | 1 (0–1) | 0 | 0 (0–1) | – | – |
mMCD | 0°~ | 6*▪ | 0°~ | 0▪°~ | – | – | |
FCDIIa | 3.5 (2–4)*~ | 7.5 (6–9)* | 1.5 (0–2)*~ | 2.5 (1–4)*~ | – | – | |
FCDIIb | 6 (4–6)*° | 9 (6–9)* | 3.5 (3–4)* | 6 (4–9)*° | 4 (3–6) | 9 (6–9) | |
TSC | 3.5 (3–4)* | 7.5 (6–9)* | 2.5 (2–4)* | 2.5 (2–4)* | 6 (4–9) | 9 (6–9) | |
β5i | Control | 0 | 0 | 0 (0–1) | 1 (1–2) | – | – |
mMCD | 0° | 0▪~ | 0 (0–1)°~ | 0°~ | – | – | |
FCDIIa | 0° | 1.5 (1–4)* | 0 (0–2)° | 0 (0–2)~ | – | – | |
FCDIIb | 0 (0–1)° | 4 (3–6)° | 2.5 (1–3)° | 3 (1–6) | 0 (0–1)° | 6 (4–6)° | |
TSC | 6 (4–9)* | 0.5 (0–1) | 6 (4–9)* | 1.5 (1–2)* | 9 (6–9) | 0.5 (0–1) |