Fig. 5
From: Metabolic determinants of the immune modulatory function of neural stem cells
Th1-like cytokines affect NSC arginine metabolism altering the levels of arginine-derived polyamines. Box plot of NSCs endo-metabolites for the arginine pathway detected by LC-MS/MS expressed as mean of MS peak intensity for five independent experiments. Agmatine (a), N-acetylputrescine (b), and 4-guanidinobutanoate (c) levels were upregulated in Th1 NSCs compared to basal NSCs. Unpaired two-tailed t test for comparisons between groups were applied. *p ≤ 0.05 and **p ≤ 0.01 vs. basal NSCs, ^p ≤ 0.05 vs. Th2 NSCs