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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Fig. 10

Telmisartan blocks oxidative changes to neurons in the spinal cords of NSV-infected mice. Immunohistochemical staining for 4-HNE, a lipid peroxidation product that accumulates in cell membranes following ROS exposure, is induced 4 days after NSV infection (b) compared to expression in uninfected control animals (a). Higher magnification views show prominent staining of neuronal cell membranes with less intense labeling of neuropil in ventral gray matter of infected animals (c). Treatment of NSV-infected mice with telmisartan (100 mg/kg/day) for 4 days blocks most of the observed 4-HNE immunoreactivity (d). Calibration bar = 250 μm in panels a, b and d; 20 μm in panel c

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Journal of Neuroinflammation

ISSN: 1742-2094