Fig. 3

Telmisartan protects mice against both moderate or severe hind limb paralysis (a) and death (b) following NSV challenge in a dose-dependent manner. Cohorts of animals (n = 15–23 mice per group) were inoculated with NSV and treated twice daily with either telmisartan or a vehicle control at the daily doses indicated. Blinded examiners scored each animal daily as described. The proportion of mice in each group that remained either normal/mildly affected (a) or alive (b) was calculated over time. Statistical differences between drug-treated groups and vehicle-treated controls were determined using a log-rank (Mantel-Cox) test. Individual p values are as follows: *p < 0.0001; **p = 0.0002; ***p = 0.0244; †p < 0.0001; ††p = 0.0148; †††p = 0.1514