Fig. 6

Telmisartan has no effect on the systemic or local CNS production of myeloid-related immune factors following NSV challenge. At peak inflammation (day 6), plasma and brain tissue was collected from mice (n = 5 mice per group) treated with telmisartan (100 mg/kg/day) compared to a vehicle control. Plasma samples were assayed without further manipulation. Tissue homogenates were first normalized to the total extracted protein content of each sample. Plasma and brain levels of myeloid-related immune factors were measured using a commercial assay according to the manufacturer’s instructions. Plasma (pg/ml) or brain (pg/mg total tissue protein) concentrations are shown. No differences in any vehicle- versus telmisartan-treated brain concentrations were identified