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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Fig. 7

Mice treated with telmisartan developed milder disease (a) and were protected from death (b) following challenge with the human alphavirus, WEEV. Mice were inoculated with WEEV and treated with either telmisartan (100 mg/kg/day) or a vehicle control. Blinded examiners scored each animal daily for both disease severity and survival. The mean ± SEM disease score (a) and the proportion of animals surviving (b) are shown (n = 8 mice/group). A two-way ANOVA confirmed that drug treatment lessened disease severity (p < 0.0001), while a log-rank (Mantel-Cox) test confirmed that telmisartan enhanced disease survival (p = 0.0139)

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Journal of Neuroinflammation

ISSN: 1742-2094