Fig. 1

MASP-2 deficiency is protective following cerebral IRI. Neurological assessment expressed as general and focal deficits (a) and infarct volumes (b) following 60-min tMCAO and 48 h of reperfusion in WT and MASP-2^−/− mice, n = 10. Representative images of cresyl violet staining in coronal brain sections for each assessed group indicate the pale staining of the infarcted area. Infarct volume measurements following 30 min of 3VO and 24 h of reperfusion (c), n = 11–12. Representative images of TTC-stained sections indicate the infarcted area. Data are reported as scatter-dot plots and means (bars). *P < 0.05; **P < 0.01, unpaired t test. MASP-2 mannose-binding lectin-associated serine protease 2, WT wild type, tMCAO transient middle cerebral artery occlusion, 3VO 3-vessel occlusion